Mar 29, 2013· To build on your aspirin comment. I can't take aspirin orally, but if I have a bad toothache, sometimes what I'll do is crush up a few aspirin into fine powder (I have a pill crusher just for this), mix it in with hot hot tap water, swish it around in the cup to dissolve the aspirin, and then take a sip and let it sit in the area of my mouth where I'm having pain for a minute or two then spit ...